LIVER FUNCTION TEST 

Test Details:

Hepatic Function Panel or Liver Function Tests (LFT) helps to determine the normal functioning of the liver. Hepatic Function Panel or Liver Function Tests (LFT) measures the amount of various liver proteins, enzymes and bilirubin in the blood.

Test Required for:

A Liver Function Test or LFT includes a series of tests to check the liver condition. Proper diagnosis is important to detect and control any type of ailment in liver. Liver function tests check the levels of certain enzymes and proteins in your blood.

Test Ordered for:

Liver Function Tests helps to know the values of various liver protein, bilirubin and enzymes in the blood.

Test Recommended:

To determine whether the liver is functioning normally or not. The list of tests include: Total Protein Test, Alkaline phosphatase (ALP), Serum Bilirubin test, Gamma-glutamyl transpeptidase (GGT) , Serum Glutamate Pyruvate Transaminase (SGPT) or ALT and Serum Glutamic Oxaloacetic Transaminase (SGOT) or AST.

  • Preparation : Fasting is preferable / as directed by physician
  • Online Report Delivery : Same Day
  • Sample Type : Blood

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Know more about Liver Function Test

What is Hepatic Function Panel or Liver Function Tests (LFT)?

Hepatic Function Panel or Liver Function Tests (LFT) helps to determine the normal functioning of the liver. Hepatic Function Panel or Liver Function Tests (LFT) measures the amount of various liver proteins, enzymes and bilirubin in the blood.

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What are the different components of Hepatic Function Panel or Liver Function Tests (LFT)?

The various tests that are included in Hepatic Function Panel or Liver Function Tests (LFT) are as follows:

 

1. S.G.O.T Test or A.S.T Test:

SGOT Test is a part of the liver function test. It's done to assess the proper functioning of the liver by measuring the amount of serum glutamic oxaloacetic transaminase enzyme in the blood.

Normal range:

5 to 40 units per litre of serum 

Deviations from the normal range:

Higher values indicate: 

  • Liver damage
  • Hepatitis A and B

 

2. S.G.P.T Test or ALT Test:

SGPT or ALT Test is a part of the liver function test. It's done to assess the proper functioning of the liver by measuring the amount of serum glutamic pyruvic transaminase enzyme in the blood.

Normal range:

7 to 56 units per litre of serum 

Deviations from the normal range:

Higher values indicate: 

  • Liver damage
  • Hepatitis A and B
  • Cirrhosis
  • Liver Cancer
  • Pancreatitis

 

3. Serum Bilirubin Test:

Bilirubin is an orange-yellow pigment that occurs normally in the blood as an integral part of RBC breakdown process. Serum bilirubin test measures the amount of bilirubin in your blood and is usually done to detect the proper functioning of the Liver.

Normal Range:

0.3 – 1.2 mg/dL

Deviations from the normal range:

High bilirubin level indicates the following conditions:

  • Jaundice 
  • Liver disease
  • Hemolytic anaemia
  • Blockage of the bile ducts
  • Gilbert's syndrome
  • Cirrhosis 
  • Gallstones
  • Cancer of the gallbladder and pancreas

 

4. Alkaline Po4 or Alkaline phosphatase Test:

Alkaline phosphatase test is usually done to detect the levels of alkaline phosphatase enzyme in the blood. This test is a part of the liver function test.

Normal range:

20–140 IU/L of blood

Deviations from the normal range:

A high value indicates:

  • Liver diseases including hepatitis, cirrhosis and Liver Cancer
  • Gallbladder problems
  • Bone Cancer
  • Ricket
  • Heart failure

A low value indicates:

  • Celiac disease 

 

5. Gamma-Glutamyltransferase (GGT):

The enzyme Gamma-glutamyltransferase (GGT) is usually seen in kidney, liver and pancreatic cells. Small amounts may be observed in other tissues. The renal tissue has the highest level of GGT. It originates primarily from the hepatobiliary system & its activity is elevated in all forms of liver disease.

Reference Values

Males

0-11 months:

12 months-6 years:

7-12 years:

13-17 years:

> or =18 years: 8-61 U/L

Females

0-11 months:

12 months- 6 years:

7-12 years:

13-17 years:

> or =18 years: 5-36 U/L

Deviation from the normal range:

Elevation of gamma-glutamyltransferase (GGT) activity indicates:

  • All forms of liver disease 
  • Highest elevations are seen in intra- or post-hepatic biliary obstruction
  • Elevated values can also indicate alcoholic cirrhosis or individuals who are heavy drinkers

 

6. Total Protein Test:

Proteins are the building blocks of the body. Total protein test measures the total amount of protein (Albumin and Globulin) present in the body and the ratio of Albumin and Globulin present in the body. This test is a part of the liver function test.

Normal Ranges:

The normal range of total protein lies in between 6 to 8.3 gm/dL. The normal A/G ratio lies in between 0.8-2.0.

Deviation from the normal range:

High total protein in the blood indicates:

  • Chronic infection or inflammation including AIDS or viral hepatitis
  • Bone marrow disorders including multiple myeloma

Low total protein in the blood indicates:

  • Liver or kidney disorder
  • A digestive disorder like celiac disease 

High A/G ratio in the blood indicates:

  • Liver, kidney and intestinal disorder
  • Leukaemia

Low A/G ratio in the blood indicates:

  • Kidney disease
  • Cirrhosis
  • Inflammatory conditions

 

Is there any special preparation required?

Overnight fasting is required for Hepatic Function Panel or Liver Function Tests (LFT).